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Owlscrying
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Ancient viruses thrive in our DNA
04/25/12 at 11:16:35
 
Traces of ancient viruses which infected our ancestors millions of years ago are more widespread in us than previously thought.

A study shows how extensively viruses from as far back as the dinosaur era still thrive in our genetic material.

It sheds light on the origins of a big proportion of our genetic material, much of which is still not understood.

The scientists investigated the genomes of 38 mammals including humans, mice, rats, elephants and dolphins.

The research was carried out at Oxford University, the Aaron Diamond AIDS Research Centre in New York and the Rega Institute in Belgium.

It is reported in the journal Proceedings of the National Academy of Sciences.

One of the viruses was found to have invaded the genome of a common ancestor around 100 million years ago with its remnants discovered in almost every mammal in the study.

Another infected an early primate with the result that it was found in apes, humans and other primates as well.

The work established that many of these viruses lost the ability to transfer from one cell to another.

Instead they evolved to stay within their host cell where they have profilerated very effectively - spending their entire life cycle within the cell.

The researchers found evidence of the viruses multiplying so extensively within mammals' genomes that they have been compared to an outbreak of disease.

The senior author of the study, Dr Robert Belshaw from Oxford University's Zoology Department, said: "This is the story of an epidemic within every animal's genome, a story which has been going on for 100 million years and which continues today.

"We suspect that these viruses are forced to make a choice: either to keep their 'viral' essence and spread between animals and species. Or to commit to one genome and then spread massively within it."

The study shows that the viruses involved have lost a gene called en vwhich is responsible for transmission between cells.

Known as endogenous retroviruses, these micro-organisms have gone on to become 30 times more abundant in their host cells.

The study is one of many attempting to understand the full complexity of the human genome.

Astonishingly, only 1.5% of the genetic material in our cells codes for human life. Half of the rest is sometimes described as "junk DNA" with no known function, and the other half consist of genes introduced by viruses and other parasites.

According to the lead author, Dr Gkikas Magiorkinis, "much of the dark matter in our genome plays by its own rules, in the same way as an epidemic of an infectious disease but operating over millions of years.

"Learning the rules of this ancient game will help us understand their role in health and disease."

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XIIIEM33092
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Re: Ancient viruses thrive in our DNA
Reply #1 - 04/28/12 at 00:00:38
 
Well I guess we were closer to our ancestors than we thought it makes me wonder really about all this if the infections can stick to our dna what else can morph into it.  I think some scientists just opened up a door. I am honestly completely baffeled at alot of the discovery's recently its groundbreaking stuff and this is a big shocker well ...too me  Grin
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Daham
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Re: Ancient viruses thrive in our DNA
Reply #2 - 04/29/12 at 12:16:02
 
DNA is the pattern which shows who we are and our identity. Some vruses attack certain families or bloodlines more tha others. I have seen this. So, immunity is created by power of genes in some people.

Viruses, even though ancient will only effect sertain families DNA and not all. I always feared a wipe of of humanity becuase of an unknown virus. And i thought many are given healing ability is to cure these sourt of deseaes. Well humans have will always find ways to surviwe and guess we definitely will have to face a few of the encient epidemics since we dig so fat into the ground everwhere in the world.
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Owlscrying
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Re: Ancient viruses thrive in our DNA
Reply #3 - 04/30/12 at 15:13:41
 
 Smiley Beautifully put Daham Smiley

There are approximately 23,000 genes in human beings, the same range as in mice and roundworms. Understanding how these genes express themselves will provide clues to how diseases are caused.

Endogenous retroviruses (ERVs) are sequences in the genome thought to be derived from ancient viral infections of germ cells in humans, mammals and other vertebrates; as such their proviruses are passed on to the next generation and now remain in the genome.

Endogenous retroviruses may be a variant of a retrovirus which became permanently integrated with its host and is inherited from generation to generation as part of the genome of the host.

Viral fossil is an informal term for pieces of genetic code (DNA insertions) of a virus in the genome of a modern-day host organism. These viruses and their insertions are called fossil viruses or paleoviruses. They may be traced to millions of years back, hence the terminology, although strictly speaking, it is impossible to detect an ancient virus in fossils. Viral fossils are among the subject of a recent field dubbed paleovirology.

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